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    A total of 7 women discontinued the study as a result of adverse effects – one of which was a result of experiencing drug-induced depression. The second study referenced by researchers was a randomized controlled trial published in 2012 evaluating the safety and efficacy of the drug Qsymia (phentermine plus topiramate). In this trial, a total of 1,267 participants received a placebo, low-dose Qsymia, or high-dose Qsymia – for a 56-week term. The primary outcome measure was weight loss, but depression was analyzed as a secondary measure based off of results from the Patient Health Questionnaire-9. Despite noticeable mood improvements after 56 weeks among participants receiving Qsymia, similar mood improvements were derived among those receiving the placebo, free weight loss programs online.  
     
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